DNA polymerase II

• • Summary: DNA Polymerase II**

DNA Polymerase II is a crucial enzyme in prokaryotic DNA replication and repair, known for its high fidelity and role in correcting errors made by other polymerases. It operates by binding to single-stranded DNA, incorporating nucleoside triphosphates with the aid of magnesium ions, and proofreading through mismatch excision. Pol II primarily functions on the lagging strand during replication and plays a key role in preventing mutations caused by less accurate polymerases like III and IV. While it shares structural motifs with eukaryotic family B polymerases, it is not naturally active in eukaryotes. Its abundance in cells and regulation through the SOS response highlight its importance in maintaining genomic stability.